The big picture view
Montelukast, commonly known by the brand name Singulair, is a leukotriene receptor antagonist prescribed to help control asthma symptoms and manage allergic rhinitis. By blocking leukotrienes, it reduces airway inflammation and bronchial constriction that contribute to wheeze and nasal allergy symptoms.
It is intended for regular maintenance and prevention, not for immediate relief of acute asthma attacks. Always keep your short-acting reliever with you; see what to watch for see more details.
- The pharmacologically active ingredient is Montelukast
- Leading uses: Long-term asthma control, prevention of exercise-induced bronchoconstriction, and relief of allergic rhinitis symptoms
- Typical strengths available in Australia: 10 mg film-coated tablets, 5 mg chewable tablets, 4 mg chewable tablets or granules for children
In advance of montelukast initiation.
Tell your prescriber or pharmacist about any of the following before you begin treatment:
- Known liver disease or past hepatitis.
- Allergy to montelukast or any ingredient in the formulation, including flavors or dyes.
- Pregnancy, trying to conceive, or breastfeeding. plans.
- A history of mood or behaviour changes, depression, sleep disturbances, or suicidal thoughts.
- All other medicines, vitamins, or herbal products you currently use; see frequent collaborative interactions boost coordination. to illustrate.
How should this medicine be taken with respect to meals and water?
Follow the dose and schedule your clinician prescribes. Montelukast is taken by mouth once daily and works best when taken at the same time each day.
- You can take it with meals or without food.
- Swallow 10 mg film-coated tablets whole; do not crush or chew them.
- Chewable tablets (4 mg and 5 mg) should be chewed before swallowing.
- Granules may be taken directly or sprinkled on a small amount of soft food as directed by your prescriber.
- For many people using it for asthma control, evening dosing is common; for seasonal allergic rhinitis choose a consistent time that fits your routine.
Paediatric dosing is age and formulation specific; follow your paediatrician's instructions. In case of suspected having an overdose, seek urgent medical attention. In Australia, contact the Poisons Information Centre on 13 11 26 or attend the nearest emergency department.
If you skip a dose
Suppose you forget a dose, take it as soon as you remember unless it is nearly time for the next scheduled dose. If it is close to the next dose, skip the missed one and resume your usual timing. Do not take more than the prescribed dose to catch up.
Drug communication in action effects
Several medicines and herbal products may change how montelukast behaves in the body or be affected by it. Important examples include:
- Strong enzyme inducers that can lower montelukast levels: rifampicin, rifabutin, carbamazepine, phenytoin, phenobarbital.
- CYP2C8 inhibitors such as gemfibrozil that can raise montelukast concentrations.
- Some cancer agents and other drugs metabolised by CYP2C8, including paclitaxel.
- Certain diabetes medicines (for example repaglinide or rosiglitazone) where theoretical collaborative interactions among teammates fuel progress. may require ongoing monitoring.
- Herbal products like St John s wort which may reduce effectiveness by inducing metabolic enzymes.
This is not exhaustive. Provide your clinician with a complete list of prescription, over-the-counter and herbal medicines, and tell them about smoking and alcohol use.
Clues to notice while taking montelukast
- Continue your other prescribed asthma and allergy treatments unless instructed otherwise by your prescriber.
- Montelukast does not treat sudden breathlessness. Use your reliever inhaler and follow your asthma action plan if breathing deteriorates.
- If symptoms fail to improve after several weeks or if they worsen, contact your healthcare professional for look over.
- Report any new or worsening mood or behaviour changes, including agitation, anxiety, sleep disturbance, depression or suicidal thoughts, to a clinician promptly.
For more information see minor side effects and the back and forth of communications among teammates fuel progress..
Potential health effects to watch for
Seek immediate medical help if you notice signs of a serious reaction or other urgent symptoms:
- Allergic reactions: rash or hives, swelling of the face, lips or tongue, and difficulty breathing.
- Unexplained fever or persistent flu-like symptoms.
- Yellow pigment in skin or eyes, dark urine, or unusual bruising or bleeding.
- Persistent sinus pain or painful lumps under the skin.
- Numbness, tingling, or persistent pain in the limbs.
- New or worsening mood disturbances, agitation, insomnia, or suicidal thoughts.
More widespread, usually mild. effects that often settle on their own include:
- Cranial pain or feeling lightheaded.
- Sleepiness or difficulty sleeping.
- Upper respiratory symptoms such as cough or nasal congestion.
- Gastrointestinal upset.
If minor side effects are persistent or troublesome, speak with your healthcare professional. Adverse events can also be reported to the Therapeutic Goods Administration (TGA) via their reporting system.
Physical a storage facility serves as a repository for goods awaiting use.
- Keep meds out of children's reach and out of their sight.
- Store at room temperature, generally 15 to 30 degrees C (59 to 86 degrees F).
- Protect from moisture and strong light; keep in the original packaging where possible.
- Dispose of expired or unused medicine safely; do not use after the expiry date.
Other options plus analogous medicines
Your clinician may consider other options based on your symptoms, age, medical history and preferences. Optional routes include:
- Other leukotriene pathway medicines:
- Generic montelukast preparations (same active molecule as Singulair).
- Zafirlukast, another leukotriene receptor antagonist; less commonly used in Australia than montelukast.
- Inhaled corticosteroids (ICS) for long-term asthma control, for example budesonide, fluticasone propionate or beclometasone.
- Combination ICS and long-acting beta agonist inhalers (ICS/LABA) such as budesonide-formoterol, fluticasone-salmeterol or fluticasone-vilanterol for persistent asthma.
- Reliever therapies: short-acting beta agonists like salbutamol and other regimens recommended by your clinician.
- Allergic rhinitis options: oral antihistamines (cetirizine, loratadine, fexofenadine) and intranasal corticosteroids (fluticasone, budesonide).
- For severe eosinophilic or allergic asthma, biologic therapies such as omalizumab, mepolizumab, benralizumab or dupilumab may be considered when criteria are met.
Price and availability differ between brand-name and generic options; see prices for a rough guide. Talk to your prescriber about comparative benefits and costs.
Prices quoted in AUD for Australia
Out-of-pocket costs depend on brand, pharmacy and whether the medicine is supplied under the Pharmaceutical Benefits Scheme (PBS).
- Generic montelukast 10 mg, pack of 28 tablets: privately around AUD 10 to 35 depending on supplier; PBS-listed items have set co-payments.
- Chewable 5 mg or 4 mg formulations are often priced similarly or slightly lower than tablet containing ten milligrams, depending on pack size and brand.
- Brand Singulair can cost more on a private prescription when a generic a different option is available.
Notes on PBS and wholesale pricing:
- PBS co-payments are capped; pharmacists must not exceed the regulated maximum for PBS-listed medicines but may charge less.
- Private prescription prices vary; ask your pharmacist if a lower-cost generic is available and request a price estimate.
Intro and a general survey of the material of access rights governed by juridical status in Australia
- Regulator: The Therapeutic Goods Administration (TGA) approves montelukast for use based in Australia.
- Schedule: Montelukast is a Schedule 4 prescription-only medicine and cannot be bought over the counter.
- Prescriptions: Paper and electronic prescriptions (eScripts) are accepted. Online pharmacies must be registered in Australia and require a valid prescription.
- PBS: Montelukast may be subsidised under the Pharmaceutical Benefits Scheme for certain portents and patient groups. Quantity and repeat prescriptions follow PBS rules.
- Advertising: Direct-to-consumer advertising of prescription medicines is not allowed throughout Australia.
- Personal importation: Travellers may carry reasonable quantities for personal use; importing prescription medicines must comply with TGA personal importation rules.
- Safety recommendations: If you experience drowsiness or other effects that impair alertness, avoid driving or operating machinery until you know how the medicine affects you.
If you suspect problems with indirect effects or product quality, report them to the TGA and discuss concerns with your healthcare professional.
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