Brief a bird's eye view of at the topic
The Mega ED Pack is a bundled selection of three established erectile dysfunction medicines supplied together so an adult man with ED can trial different phosphodiesterase type 5 inhibitors and find the most suitable option. The primary active substances included are sildenafil, tadalafil, and vardenafil.
- Bioactive ingredients included: sildenafil, tadalafil, vardenafil
- Main purpose: treatment of erectile dysfunction
- Typical strengths in the bundle: sildenafil 100 mg, tadalafil 20 mg, vardenafil 20 mg (see the package contents section at items found inside the pack)
For urgent safety mattersexecute a review Medical reasons to refrain from use and Significant pharmacokinetic and pharmacodynamic effective engagement and communications require clear communication. between drugs to note.
Contents in the pack
The pack brings three separate PDE5 inhibitor products together for convenience. Each medicine is provided as a distinct boxed product; you should only use one of them at a time.
- Levitra (vardenafil) 20 mg, usually supplied as 30 film coated tablets
- Viagra (sildenafil) 100 mg, usually supplied as 30 film coated tablets
- Cialis (tadalafil) 20 mg, usually supplied as 30 film coated tablets
Do not take more than one PDE5 inhibitor on the same day. For directions on timing and frequency, see How to take correctly and determine dosage directions.
How these medicines work
Sildenafil, tadalafil and vardenafil act by blocking the PDE5 enzyme in penile tissue. This promotes relaxation of smooth muscle and increases blood flow into the corpus cavernosum during sexual stimulation. None of these drugs will produce an erection without sexual arousal.
Dosage and practical directions
Carry out the instructions your prescriber or pharmacist provides. General on demand guidance:
- Timing: take sildenafil or vardenafil about 30 to 60 minutes before sexual activity; some individuals may find effects start earlier or later. Tadalafil may be effective up to 36 hours after a single dose.
- Frequency: do not take more than one dose in 24 hours and avoid using different ED tablets on the same day.
- Food and drink: large, fatty meals tend to delay onset for sildenafil and vardenafil. Liquor can reduce effectiveness and increase unwelcome possible side effects.
If you are uncertain which medicine to try first, consult your clinician. Tadalafil is known for a longer duration of action while sildenafil and vardenafil commonly have shorter windows of effect.
Hazard prevention measures before using any item from the pack
Pre-start any of these medicines, tell your healthcare professional if you have had or currently have:
- Cardiac disease, recent myocardial infarction, stroke, irregular heartbeat, angina, or heart failure
- Very high or low blood pressure or pulmonary hypertension unless tadalafil is prescribed for that condition
- Pulmonary venous occlusion disease
- Moderate to severe kidney or liver impairment
- Eye conditions such as non arteritic anterior ischemic optic neuropathy, retinitis pigmentosa, or unexplained vision loss
- Bleeding disorders or blood dyscrasias including sickle cell anaemia, multiple myeloma or leukaemia
- Penile deformity such as Peyronie medication or a history of prolonged erections
- Peptic ulcer disease that is currently active
- Any condition that makes sexual activity unsafe
Discontinue use and obtain immediate medical attention if you develop chest pain, sudden loss of vision or hearing, or an erection lasting more than four hours.
Relative absolute contrasigns
- Known allergy to sildenafil, tadalafil, vardenafil or any tablet component
- Concurrent use of any nitrate medicine, including isosorbide mononitrate or glyceryl trinitrate, or use of recreational nitrates such as amyl nitrite; combining these can cause dangerous drops in blood pressure
- Concurrent use with the guanylate cyclase stimulator riociguat
If any of the above apply, do not take medicines from this pack and contact a healthcare professional for a side option management.
Possible collateral effects
Most secondary consequences are mild to moderate and resolve quickly. Frequent reactions include:
- Head pain with facial flushing
- Nasal airway obstruction
- Abdominal malaise along with indigestion and nausea
- Backache or muscle aches
- A sense of dizziness
Obtain urgent care for severe chest pain, fainting, signs of an allergic reaction, sudden changes in vision or hearing, or priapism (an erection lasting longer than four hours). Additional references Prior to use, observe these protective protocols.
Critical potential conversational exchanges are not just about words, but meaning. among medications to note
Always inform the prescriber and pharmacist about all medicines, supplements and recreational substances you use. Key interaction risk factors include:
- Other erectile dysfunction therapies or drugs for pulmonary arterial hypertension
- Certain antibacterials and antifungals such as clarithromycin, erythromycin, itraconazole and ketoconazole
- Some HIV and hepatitis C antivirals including ritonavir and cobicistat
- Alpha blockers and other antihypertensive therapies; medicines for urinary symptoms
- Anticonvulsant drugs that alter liver enzymes
- Nitrates and riociguat, which are contraindicated (see Cautions against use due to medical reasons)
- Grapefruit juice, which may increase blood levels of some PDE5 inhibitors
Dose not taken information and guidance
These medicines are usually taken when required and not on a fixed schedule. If you miss taking a dose before planned sexual activity, take the medicine the next time it is needed, adhering to the timing and frequency rules in Dose amount and directions.
In the event of an drug overdose: what to do
If an non fatal overdose is suspected, go to the nearest emergency department immediately. Bring the medicine packaging or a list of the tablets taken to assist clinicians.
Memory seasonal storage spaces provide room for off-season items. and handling tips
- Store at room temperature in a dry location away from direct heat and moisture.
- Keep medicines in their original blister packs or containers and out of reach of children.
- Do not use after the expiry date shown on the box.
Alternate therapies and related medications
If one component of the Mega ED Pack is unsuitable, other options exist in the UK. Discuss these with your clinician:
- Avanafil (brand Spedra) — a PDE5 inhibitor with rapid onset in some men
- Daily low dose tadalafil (2.5 mg or 5 mg) for men who prefer spontaneity or who have lower urinary tract symptoms related to BPH
- Generic formulations of sildenafil and tadalafil available at lower cost compared with branded products
- Vardenafil generics where available as the other way choices to Levitra
- Non drug therapies such as vacuum erection devices, intracavernosal injections (alprostadil), psychosexual therapy, and lifestyle changes including weight loss, smoking cessation and regular exercise
Never combine two ED medications on the same day. If adverse symptoms occur, speak to your prescriber about dose changes, switching medicines, or exploring non pharmacological options. For standing under the law of these medicines in the UK see Information pertaining to the law pertaining to the United Kingdom.
Prices in the UK: approximate guide
Retail prices vary by pharmacy, whether the product is branded or generic, with the addition of the pack size. The ranges below are indicative per tablet prices in GBP and subject to change:
- Generic sildenafil 100 mg: about 0.30 to 1.50 pounds per tablet; branded Viagra 100 mg: roughly 5 to 10 pounds per tablet
- Generic tadalafil 20 mg: about 0.50 to 2.00 pounds per tablet; branded Cialis 20 mg: roughly 5 to 12 pounds per tablet
- Vardenafil 20 mg generics (if stocked): around 1 to 3 pounds per tablet; branded Levitra 20 mg: around 3 to 8 pounds per tablet
- Mega ED Pack (90 tablets total) composed of generics may cost in the order of 70 to 180 pounds depending on supplier and offers; using only branded products will be considerably more expensive
Note NHS prescription rules differ across the UK: in England a prescription charge may apply per item unless you are exempt; in Scotland, Wales and Northern Ireland prescriptions are generally free. Some NHS services may prescribe generic sildenafil at low cost when clinically appropriate. Always cross check your work. current local fee schedule and prescription policies.
UK legal data
- Prescription status: Most PDE5 inhibitors, including sildenafil (most strengths), tadalafil and vardenafil, are Prescription Only Medicines (POM) in the UK.
- Pharmacy supply without prescription: Sildenafil 50 mg is available as a pharmacy medicine (Viagra Connect) after an assessment by a pharmacist to men aged 18 and over. Certain strengths of tadalafil may be supplied under pharmacist supervision in branded pharmacy schemes.
- Online supply: UK online pharmacies must be registered with the General Pharmaceutical Council and typically require an online consultation for POMs.
- Avoid unregulated sellers: counterfeit ED tablets are common. Verify the pharmacy's GPhC registration and the MHRA distance selling logo.
- Import for personal use: Bringing medicines into the UK carries restrictions; small personal quantities of licensed medicines are typically tolerated but importing unlicensed products can lead to seizure. A practical rule is to limit imports to a three month personal supply and to use UK licensed products where possible.
- Age and safety: These medicines are intended for adult men. Use is contraindicated with nitrates and in the presence of other specified medical conditions (see Reasons to avoid use).
- Driving and sports: Some users may experience dizziness. Elite athletes should confirm current anti doping rules, although PDE5 inhibitors are generally permitted; check with the relevant governing body.
This information is educational and not a replacement for individual clinical advice. Always follow the guidance of your UK prescriber or pharmacist.
Quick facts sheet in brief
- Indication: erectile performance issues
- Only take one tablet from one product before sexual activity; do not mix products the same day
- Avoid with nitrates or riociguat
- Dial emergency services for chest pain, sudden vision or hearing loss, or an erection lasting more than four hours
- See Packing and how to store items properly to keep medicines safe at home
- Modalert Negative effects and Related Body Reactions
- A look at Chloroquine: purpose and FDA status
- What Super Levitra Does to the Body: Medication unintended effects and Beyond