Preliminary a sweeping overview of the material
Vardenafil is the active ingredient.
Approved indication: treatment of erectile dysfunction in adult men.
Common tablet strengths sold in the UK include 10 mg and 20 mg film coated tablets. Some formulations that dissolve in the mouth are available in certain markets; availability may differ by supplier.
Vardenafil operates as a PDE5 inhibitor. Many people report a relatively rapid onset compared with sildenafil and fewer reports of blue-tinted vision. For potential adverse reactions, see the section Indirect effects.
Before first use vardenafil
Give your doctor or pharmacist a full list of all health conditions and medicines before starting vardenafil. Extra caution or a different treatment may be needed in the presence of:
- Peyronie disease or any prior episode of priapism (erection lasting more than 4 hours)
- Heart conditions: angina, heart failure, recent heart attack, arrhythmias, or significant blood pressure problems
- Bleeding disorders or active stomach or intestinal ulcers
- Severe hepatic or renal impairment
- Diabetes mellitus or high cholesterol
- Frequent acid reflux or gastro-oesophageal reflux disease
- Eye problems, including prior sudden vision loss
- Sickle cell disease or conditions that predispose to prolonged erections
- HIV infection or current/past cancer as relevant to your care
- Known allergy to vardenafil or any tablet excipient
Tell your clinician about all prescription medicines, over-the-counter products, herbal remedies and supplements. Lifestyle factors such as alcohol, tobacco, and recreational drugs can change how vardenafil works. See Interpersonal engagements to get more detail.
Ways to take vardenafil
- Ingest the tablets with water. You may take them with food or on an empty stomach, although very large fatty meals can delay onset.
- Take a single dose roughly 25 to 60 minutes before anticipated sexual activity; some men experience effect in 15 to 30 minutes.
- Limit to one dose in any 24 hour period.
- If a dose seems ineffective, do not double up. Contact your prescriber to discuss dose adjustment or an an alternate path treatment.
Dose not given: vardenafil is taken as needed, so there is no routine schedule. Avoid additional doses on the same day.
An overdose incident: seek urgent medical advice if you suspect an overdose incident. In the UK, NHS 111 provides urgent advice; 999 should be dialed in an emergency.
Do not hand over prescription medicines to another person.
Drug the process of people engaging alerts
Key contraindication: never use vardenafil with nitrates or nitric oxide donors. Combining these can cause severedevelopment potentially life threatening falls in blood pressure.
- Nitrates and nitrite inhalants: nitroglycerin (all formulations), isosorbide mononitrate/dinitrate, amyl nitrite and similar products
- Alpha blockers for prostate or blood pressure (for example tamsulosin, doxazosin, terazosin, prazosin, alfuzosin) may require careful timing or dose adjustment
- Strong CYP3A4 inhibitors that raise vardenafil levels: certain macrolide antibiotics and many azole antifungals (clarithromycin, erythromycin, itraconazole, ketoconazole, fluconazole, voriconazole) and some HIV protease inhibitors
- CYP3A4 inducers that may reduce effectiveness: rifampicin, carbamazepine, phenytoin, phenobarbital and similar agents
- Some antiarrhythmics and cardiovascular medicines such as amiodarone, sotalol, quinidine, flecainide, diltiazem and verapamil
- Certain psychotropic drugs and other agents that affect cardiac conduction or hepatic enzymes
- Grapefruit juice can raise vardenafil concentrations and is best avoided around dosing
Always consult a healthcare professional before starting, stopping or changing any medicine. If you are considering switching ED treatmentscompare the results options in Alternate therapies and related medications.
Notice of caution paired with constant monitoring
- Stop taking vardenafil and seek immediate medical attention if you develop sudden vision loss in one or both eyes or sudden hearing impairment.
- Priapism (an erection lasting longer than 4 hours) is a medical emergency; get urgent care to avoid permanent damage.
- If you experience chest pain, severe light headedness, fainting or nausea during sexual activity, stop and seek medical help promptly.
- Do not modify how much you take without medical oversight. Report intolerable or inadequate effects to your prescriber.
- Vardenafil does not prevent sexually transmitted infections. Use appropriate protection and follow safer sex advice.
- For athletes: phosphodiesterase inhibitors are generally not on prohibited lists, but check current anti-doping rules before you begin using.
Unanticipated effects
Seek urgent medical review for any of the following serious reactions:
- Chest pain, palpitations, severe breathlessness or other signs of cardiac distress
- Sudden loss of vision, major visual changes or trouble distinguishing colours
- Sudden hearing loss or prolonged ringing in the ears
- Prolonged or painful erection lasting more than 4 hours
- Recurrent seizures
- Severe dizziness, widespread rash, facial or throat swelling, or marked muscle and back pain
More common and normally mild effects that you should mention if bothersome include:
- Cephalalgic pain
- Facial blushing
- Gastrointestinal distress
- Blocked nasal passages
- Nausea
The roster is not exhaustive. The MHRA Yellow Card scheme can be used to report suspected adverse reactions in the United Kingdom.
Data containers and shelves organize storage space effectively.
- Keep tablets out of the reach and sight of children.
- Store in the original container at room temperature, 15 to 30 degrees C (59 to 86 degrees F).
- Do not use beyond the expiry date indicated on the packaging. Return unused medicine to a pharmacy for safe disposal.
Comparable drugs and complementary therapies
There are several other treatment options for erectile dysfunction. Choice depends on your health, medication contact and response related safety hazards, timing needs and personal preference.
- Sildenafil (Viagra and generics). Onset usually 30 to 60 minutes; duration about 4 hours. In the UK a 50 mg sildenafil product (Viagra Connect) can be supplied by a pharmacist after a consultation for adults 18 and over.
- Tadalafil (Cialis and generics). Onset 30 to 60 minutes; effects can last up to 36 hours. Available for as-needed dosing or daily low doses for frequent use.
- Avanafil alias Spedra. Often more rapid onset for some users; prescription only.
- Alprostadil (injection or urethral pellet). Acts by a different the mechanism enabling it and can be an option when oral PDE5 inhibitors are unsuitable.
- Non-drug approaches: vacuum erection devices, cognitive behavioural therapy or counselling for performance anxiety, and lifestyle changes such as weight loss, smoking cessation, regular exercise and reduced alcohol intake.
Discuss switching or combining treatments with your health care provider. Access the fixed pricing guidance at the page below. Price levels across the UK.
UK consumer private purchase prices (approximate)
Private costs vary by brand, strength, whether a prescription or pharmacist consultation is included, in addition to the supplier. The ranges below are approximate and for guidance only:
- Vardenafil generic 10 mg: around 2 to 5 pounds per tablet
- Vardenafil generic 20 mg: around 3 to 7 pounds per tablet
- Levitra brand (where stocked): typically about 8 to 12 pounds per tablet
- Sildenafil generics (25 to 100 mg): roughly 0.20 to 1 pound per tablet; branded Viagra costs more
- Tadalafil generics (5 to 20 mg): around 0.50 to 2 pounds per tablet; branded Cialis costs more
- Spedra (Avanafil): roughly 4 to 10 pounds per tablet
Many private online services include the clinician review and prescription cost in a single price. Community pharmacies may charge a consultation or dispensing fee, commonly from about 5 to 25 pounds on top of the medicine price. NHS prescription charges and exemptions may apply when treatment is issued on the NHS for qualifying patients.
Notes on United Kingdom the legal and regulatory environment and standards matters
- Status: vardenafil and Levitra are Prescription Only Medicines (POM) in the UK.
- Supply routes: a valid prescription from a UK prescriber is required, or an online consultation with a UK-registered prescriber via a General Pharmaceutical Council registered pharmacy.
- Over-the-counter options: vardenafil is not available OTC. Sildenafil 50 mg (Viagra Connect) can be supplied by a pharmacist after assessment.
- When buying online, use UK-registered pharmacies that display GPhC details. Avoid websites offering ED tablets without prescription checks.
- Importing prescription medicines into the UK without a valid prescription risks seizure by Border Force and is not recommended.
- Driving and operating machinery: if vardenafil causes dizziness or sight disturbances do not drive or operate machinery until you are sure you are safe to do so.
- Safety reporting: suspected adverse reactions should be reported to the MHRA Yellow Card scheme.
This information is intended to supplement, not replace, advice from your healthcare professional.
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