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The active pharmaceutical ingredient is tadalafil. Primary indication: erectile dysfunction (ED). Tadalafil is also prescribed for some cases of benign prostatic hyperplasia (BPH) and, under specialist supervision, for pulmonary arterial hypertension (PAH).
Some internet listings use the name "Cialis Black" and may claim unusual strengths such as 800 mg. This is not an approved strength in Australia and strongly suggests a nonstandard, unregulated or counterfeit product. In Australia, prescription tadalafil is normally supplied in 2.the medication is offered in 5 mg, 5 mg, 10 mg, and 20 mg strengths.
In short: tadalafil helps erectile response by improving blood flow where needed, but it does not increase sexual desire. For administration details and timing see How to take care of yourself and dosage directions.
What happens and what makes it work
Tadalafil belongs to the phosphodiesterase type 5 (PDE5) inhibitor class. By inhibiting PDE5 it helps maintain levels of cyclic GMP, which promotes relaxation of smooth muscle in blood vessels supplying erectile tissue. The medicine improves the physical response to sexual stimulation; it is not an aphrodisiac and requires sexual arousal to work.
Dose timing and directions
Respect your prescriber's instructions. Do not increase dose or frequency without medical advice. Tablets can be taken with or without food and should be swallowed whole unless the product is specifically scored and a pharmacist has advised splitting.
Common regimens used in Australia for ED prescriptions:
- On-demand option: typically 10 mg taken at least 30 minutes before sexual activity; depending on effect and tolerability this may be adjusted to 5 mg or 20 mg.
- Daily low-dose option: 2.5 mg or 5 mg once each day, taken at the same time each day irrespective of planned sexual activity.
Warning: avoid products labeled with excessive strengths such as 800 mg. Such doses are not authorised and may be harmful. See Legislation information for Australia and Safety guidelines for more information on safety.
Preventive care measures
Inform your doctor if you have any relevant medical history. Dose modification or avoidance may be necessary in the following situations:
- Recent cardiovascular events (heart attack, stroke), unstable angina, severe heart failure, or serious arrhythmias.
- Significant blood pressure problems, either low or high.
- Severe impairment of liver function or renal failure, including dialysis.
- Eye conditions such as retinitis pigmentosa or prior episodes of non-arteritic anterior ischemic optic neuropathy (NAION).
- History of priapism or penile structural disorders (for example, Peyronie disease).
- Bleeding disorders, active stomach ulcers, or certain blood diseases (sickle cell disease, leukemia, multiple myeloma).
- Pulmonary veno-occlusive disease or if you are being treated for pulmonary hypertension with other drugs unless directed by a specialist.
Seek urgent care if you notice sudden vision or hearing loss, chest pain, fainting, severe dizziness or an erection lasting longer than 4 hours.
Situations in which this treatment is not advised
- History of allergy to tadalafil or any ingredient in the tablet.
- Concurrent use of any nitrate medicines (for example nitroglycerin or isosorbide mononitrate/dinitrate) or inhaled amyl nitrite/recreational nitrites due to risk of severe low blood pressure.
- Concurrent use with riociguat, a soluble guanylate cyclase stimulator, because of risk of excessive blood pressure lowering.
If any contraindication applies, discuss safer an alternate approach choices under Choices and fixed pricing in Australia.
Potential ripple effects
The majority of chronic side effects are mild and temporary in nature. Commonly observed reactions include:
- Migraine plus warmth or flushing
- Nasal obstruction
- Stomach upset with nausea and abdominal discomfort
- Muscle aches, back pain or limb pain
Seek medical help for severe or worrying signs such as chest pain, sudden loss of vision or hearing, allergic swelling, seizures or a painful erection lasting more than 4 hours.
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Tell your clinician about all current treatments including over-the-counter, herbal and complementary medicines. Important the process of people engaging categories include:
- Nitrates and riociguat: strictly contraindicated (see Preventive steps and situations where this treatment is not advised).
- Other PDE5 inhibitors or medicines used for PAH: combined use increases the risk of negative health impacts.
- Strong CYP3A4 inhibitors (for example certain macrolide antibiotics, azole antifungals, some HIV protease inhibitors) can raise tadalafil levels; strong inducers (for example some anticonvulsants) can lower tadalafil exposure.
- Antihypertensive agents and alpha-blockers: additive blood pressure lowering may occur; start at low doses and monitor blood pressure closely.
- Certain antivirals used in hepatitis C or HIV treatment may interact substantially; specialist advice is recommended.
If you are unsure about social interactions at scale reveal systemic patterns., ask a pharmacist to check your medicines before starting tadalafil or switching brands.
Dose skipped in schedule
- On-demand dosing: there is no fixed schedule; take a single dose when needed and do not take more than one dose in a 24 hour period unless your prescriber tells you otherwise.
- Once-daily dosing: if you miss your scheduled daily tablet take it as soon as you remember unless it is nearly time for the next dose. Do not take two tablets to make up a dose was skipped.
Excessive dose of medication
If an experiencing an overdose is suspected, seek emergency medical assistance or contact the Poisons Information Centre in Australia on 13 11 26. Symptoms of experiencing an overdose may include severe dizziness, fainting or prolonged and painful erections.
External storage capacity determines how much you can keep.
- Keep tablets at room temperature, away from direct heat and moisture.
- Store medications in their original packaging and out of reach of children and pets.
- Do not use after the expiry date printed on the box.
Choices and inflation-adjusted prices in Australia
Several medicines are used to manage erectile dysfunction. Below are approximate retail price bands in Australian dollars (A$). Actual costs vary by pharmacy, brand, pack size and whether a private prescription or an online supplier is used.
- Tadalafil generic (10-20 mg on-demand; 2.5-5 mg daily): roughly A$1.50 to A$6.00 per tablet depending on pack size and supplier.
- Cialis (branded tadalafil) 10-20 mg: often higher, for example A$8 to A$20 per tablet; daily 5 mg branded tablets may cost A$2 to A$6 each.
- Sildenafil (generic Viagra) 50-100 mg: approximately A$1.00 to A$4.00 per tablet; branded Viagra commonly costs A$10 to A$18 per tablet.
- Vardenafil (Levitra) 10-20 mg: less commonly stocked; where available expect around A$6 to A$15 per tablet.
- Avanafil (Stendra): availability in Australia is limited; when supplied it may be more expensive than older agents and prices vary by supplier.
Notes:
- Products labelled "Cialis Black 800 mg" are not recognised, are likely counterfeit and should be avoided.
- ED medicines are generally not subsidised under the Pharmaceutical Benefits Scheme (PBS) for most patients; check with your pharmacist for exact price points and generic options.
- Discuss with your prescriber which medication, dose and dosing schedule best suit your medical profile.
For guidance on safe purchasing and rules for importing medicines for personal use, see Legal resources in Australia.
Australian law information
Tadalafil is classified as a Schedule 4 prescription-only medicine in Australia and is regulated by the Therapeutic Goods Administration (TGA). A valid prescription from an Australian-registered prescriber is required to lawfully obtain tadalafil from Australian pharmacy networks.
Only TGA-registered products and strengths (commonly 2.5 mg, 5 mg, 10 mg and 20 mg) may be supplied. Unapproved strengths or unlisted products might be illegal to import or supply.
Online purchasing: buy only from reputable Australian pharmacies or suppliers who verify prescriptions. Pharmacists must check and confirm prescriptions before dispensing.
Personal importation: under the TGA Personal Use Import Scheme you may import up to a three month supply of a prescription medicine at one time for personal use, provided you have a valid prescription and the medicines are for personal use. Border authorities may seize products that do not meet requirements.
Advertising and promotion of prescription medicines directly to consumers is restricted. Use prescription medicines only as directed by a qualified prescriber and do not share prescription medicines with others.
If you doubt whether a product is approved, consult the Australian Register of Therapeutic Goods (ARTG) or ask a pharmacist for verification.
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