Executive view and functioning
Co-amoxiclav is the generic designation for the combination of amoxicillin and clavulanic acid, commonly known by the brand name Augmentin. Amoxicillin interferes with bacterial cell wall synthesis. Clavulanic acid is a beta-lactamase inhibitor that protects amoxicillin from enzymatic breakdown, extending activity against organisms that would otherwise inactivate plain amoxicillin.
In UK clinical practice co-amoxiclav is frequently used when a broader spectrum agent is required or when beta-lactamase production is suspected. It is used both in primary care and in hospitals, guided by local antimicrobial stewardship policies.
- Predominant active ingredients: amoxicillin and clavulanic acid
- Therapeutic category: antibacterial with beta-lactamase inhibitor
- Also called: co-amoxiclav (generic) and Augmentin (brand)
Review before you begin the task. safety information to know under Safety first before use and Unconditional contratraces.
Diseases it treats
Co-amoxiclav is prescribed for a variety of bacterial infections when its spectrum is appropriate. Everyday indicators include:
- Respiratory tract infections: community-acquired pneumonia, acute sinusitis, and acute exacerbations of chronic bronchitis
- Dermal and subcutaneous tissue infections such as cellulitis, bite wounds, and infected ulcers
- Middle ear infections
- Dental infections and some procedures where prophylaxis is recommended
- Selected urinary and intra-abdominal infections, often as part of combination regimens
- Some post-operative wound infections
Use should be reserved for confirmed or strongly suspected bacterial disease and aligned with local guidance to limit antimicrobial resistance.
Formulations on hand with the addition of their strengths
In the UK co-amoxiclav is supplied in several forms for different patient groups and clinical settings.
- Oral tablets: commonly 250 mg/125 mg and 500 mg/125 mg (sometimes referred to by combined weights of amoxicillin plus clavulanate)
- Liquid oral suspension: examples include preparations that deliver 400 mg/57 mg per 5 ml after reconstitution for children
- Intravenous formulations: used in hospital where parenteral therapy is required
Other markets may provide 875 mg/1each tablet contains 25 mg. If you receive a pack that differs from expectations, consult your pharmacist for clarification.
Co-amoxiclav intake guidelines
Dosage is determined by the prescriber and depends on the infection type, severity, patient weight, and kidney function.
- Follow the prescription exactly; do not change dose or stop early unless advised.
- Tablets are usually given two or three times a day at evenly spaced intervals. Take with food to reduce stomach upset.
- Do not crush or split non-chewable tablets unless a pharmacist instructs otherwise. Chewable formulations should be chewed.
- Renal impairment frequently requires dose adjustments or longer intervals between doses; check with your clinician present.
A common adult regimen for community infections is 500 mg/125 mg three times daily for 5 to 7 days, but your prescriber may recommend a different plan. If you are unsure about timing or i skipped the doses see Dose not taken care plan.
Before using, observe practical safety hazard controls
Discuss the following with your prescriber or pharmacist before using co-amoxiclav.
- Allergy history: report any allergy to penicillins, cephalosporins, or previous serious reactions to antibiotics.
- Liver concerns: use with caution after prior episodes of cholestatic jaundice or if significant hepatic impairment exists.
- Infectious mononucleosis: amoxicillin-containing products commonly cause a rash in this condition and are usually avoided.
- Diarrhoea presentation: antibiotic-associated colitis including Clostridioides difficile can occur; seek advice for severe or persistent diarrhoea.
- Prenatal to lactation care: co-amoxiclav may be used when benefits outweigh risks; follow medical advice.
- Activities: co-amoxiclav does not typically impair driving, but do not drive if you feel dizzy or unwell.
When in doubt, consult your clinician and see Absolute contraindication for situations when the medicine should not be used.
Unconditional situations where this treatment is not advised
- Known severe hypersensitivity to amoxicillin, clavulanic acid, or any penicillin-class antibiotic
- Previous cholestatic jaundice or severe hepatic dysfunction associated with co-amoxiclav
- Confirmed infectious mononucleosis where rash risk is high with amoxicillin products
If you meet any of the above, do not take co-amoxiclav and seek a new possibility therapy under medical supervision.
Possible negative effects
Common side effect types include nausea, vomiting, diarrhoea, abdominal pain, bloating, and i am suffering from a headache. Minor skin rashes and yeast infections (oral or vaginal) have been reported after antibiotic use.
Less frequently seen but more serious reactions include liver enzyme elevations, hepatitis, cholestatic jaundice, and severe allergic reactions such as anaphylaxis. Seek urgent medical care if you experience breathing difficulty, facial or throat swelling, widespread skin eruption, or signs of severe liver injury (jaundice, dark urine, pale stools).
If troubling or severe after effects appear, stop the medicine and contact your healthcare provider immediately. To address the exchange that happens when people meet concerns, see the reference material. Essential the study maps how social interactions evolve over time. to consider.
High priority a reciprocal exchanges across departments improve alignment.
Be sure to tell your prescriber about all drugs and supplements you use daily. Key dialogues include:
- Probenecid formulation: reduces renal elimination of amoxicillin and can raise blood levels.
- Vitamin K antagonists (e.g. warfarin): antibiotics may alter gut flora and affect INR; monitoring in real time and dose adjustment may be necessary.
- Allopurinol: co-administration has been associated with an increased incidence of rash.
- Methotrexate (MTX): penicillins can reduce renal clearance of methotrexate, increasing toxicity risk.
- Oral contraceptives: severe vomiting or diarrhoea may reduce hormonal contraceptive efficacy; use backup methods if it is needed.
- Certain live oral vaccines: antibiotic therapy can reduce live oral vaccine effectiveness; time vaccinations appropriately.
Always present a complete medication list when obtaining prescriptions or pharmacy advice.
What to do after you miss a dose
Should you miss a dose, take it promptly when you remember, unless the next dose is due soon. Do not take two times your usual dose to cover the dose was missed. Continue the remaining doses at the usual times. If you are unsure, contact your pharmacist or prescriber.
What to do in case of an taking an overdose
Symptoms of overdose case may include severe nausea, vomiting, diarrhoea, drowsiness, agitation, tremor, or seizures (especially in renal impairment). Crystalluria and kidney effects have been reported in very large ingestions. If overdose case is suspected, seek immediate medical attention or contact emergency services.
Instructions for seasonal storage spaces provide room for off-season items.
- Tablets: keep at normal room temperature away from moisture and direct sunlight, ideally 15 to 30 C (59 to 86 F).
- Ensure medicines are kept out of children's reach.
- Reconstituted oral suspension: usually refrigerated and used within the time stated on the label, commonly 7 to 10 days; do not freeze.
- Discard any medicine that is past its expiry date and return unused supplies to a pharmacy for safe disposal.
Different drugs and medicines of a similar class
Generic co-amoxiclav contains the same actives as Augmentin and is widely available in the UK. Depending on the infection and allergy status, clinicians may select other antibiotics. Standard different avenues include:
- Amoxicillin alone: narrower spectrum and will not cover beta-lactamase producing organisms
- Macrolides such as clarithromycin or azithromycin: an option in some penicillin-allergic patients
- Doxycycline: used for certain respiratory infections and for tick-borne illnesses; contraindicated in pregnancy and young children
- Nitrofurantoin or trimethoprim: often used for uncomplicated lower urinary tract infection when appropriate
- Cephalosporins such as cephalexin or cefuroxime: additional alternatives but use caution in severe penicillin allergy
- Metronidazole: provides anaerobic coverage and is commonly combined with other agents for intra-abdominal infections
Selection should follow culture results and local antimicrobial stewardship policies. Cost and availability may influence the choice; see Prices and access to UK services for typical costs.
Prices and access within Britain
Co-amoxiclav is classified as a Prescription Only Medicine (POM) in the UK and must be supplied against a valid prescription. How much you pay depends on whether you use the NHS or pay privately.
- NHS prescriptions in England: where charges apply the standard item charge is commonly around 9.90 GBP for each prescription item (check current NHS guidance for exact fees).
- NHS in Scotland, Wales, and Northern Ireland: prescriptions are free for eligible residents under local schemes.
- Private prescriptions and retail prices vary by pharmacy and pack size. Indicative private price windows in GBP are:
- 21 tablets of co-amoxiclav 500 mg/125 mg, generic, price approximately 6 to 20 GBP.
- Brand Augmentin 500 mg/125 mg, 21 tablets: approximately 25 to 45 GBP
- Oral suspension (e.g. 400 mg/57 mg per 5 ml): around 6 to 18 GBP per reconstituted bottle
Approximate private prices for some backup options:
- Amoxicillin 500 mg, 21 tablets: 2 to 6 GBP
- Fourteen capsules of doxycycline 100 mg, priced at 5 to 12 GBP.
- Clarithromycin 500 mg tablets, 14 count, 6 to 15 GBP
- Nitrofurantoin 100 mg MR, pack of 14 capsules, priced 8 to 18 GBP
These are approximate guides only. Online pharmacies and private providers should be UK-registered merged with their prices will vary by location and availability. For regulated online suppliers see Insights into legal and regulatory governance affairsrmation for the UK.
Legal and regulatory commentary for the UK
Key legal points to consider when obtaining co-amoxiclav in the UK:
- Status: co-amoxiclav/Augmentin is a Prescription Only Medicine (POM) and cannot be legally supplied without a prescription from a UK-registered prescriber.
- Regulation: legitimate internet pharmacies and dispensing services should show registration with the General Pharmaceutical Council (GPhC). Prescribers and clinical services are regulated by bodies such as the Care Quality Commission (CQC) where applicable.
- MHRA oversight: the Medicines and Healthcare products Regulatory Agency (MHRA) is the UK authority for drug safety and licensing; packaging and marketing are overseen by MHRA rules.
- Travel and sport: carry medicines in original packaging with labels and a copy of the prescription. For athletes, antibiotics are generally permitted by anti-doping agencies but keep documentation if tested.
- Disposal: return unused antibiotics to a pharmacy; do not flush them or throw in household waste.
Confirm registrations on the GPhC or MHRA websites if you are unsure about a supplier.
Core facts to know at a glance
- The active pharmaceutical ingredients are amoxicillin and clavulanic acid
- Common UK tablet strengths: 250 mg/125 mg and 500 mg/125 mg
- Prescription requirement: POM in the UK
For reminders on dosing interruptions and temporary storage helps stage tasks before final processing. see Tips for dealing with a skipped dose and File keeping materials in storage ensures their availability for future operations. handling instructions.
- Amoxil: Uses, Secondary effects, and More
- A Closer Look at Propranolol: Potential adverse effects and Health Impacts
- 2026 spotlight: 7 Viagra Jelly varied options doctor approved