Overview page

Medicine name: Accutane is a well known brand for the oral retinoid isotretinoin; equivalent generic products include Oratane and other registered generics.

Isotretinoin constitutes the active ingredient.

Primary use: treatment of severe nodulocystic or treatment-resistant acne. It is a prescription systemic medicine used under clinician supervision.

Common capsule strengths: 5 mg, 10 mg, 20 mg, 30 mg and 40 mg.

Agile navigation: view side effect details at Collateral effects or other treatment options at Equivalent medicines and further options.

Before kicking off, convey important details to your clinician.

Before isotretinoin is prescribed, disclose the following to your prescriber or pharmacist so they can assess safety and ongoing monitoring program needs.

If you are unsure about any item, ask your prescriber to clarify. For pregnancy prevention and testing requirements see Access to legal resources in Australia.

Isotretinoin administration guide

Swallow capsules whole with a glass of water and follow the directions on your prescription label. Taking the capsule with food increases absorption and may reduce stomach upset.

Maintain a consistent dosing schedule, for example taking doses at the same time each day. Do not chew or crush capsules and do not take more frequently than prescribed.

Adolescents: clinicians may prescribe isotretinoin for teenagers from about 13 years of age if indicated, with extra observation and tracking.

Overdose risk: in Australia contact the Poisons Information Centre on 13 11 26 or arrive at the nearest emergency department if you suspect an overdose event.

Not taken at scheduled time - what to do

As soon as you forget a dose, take it as soon as you remember, unless the next scheduled dose is due within about four hours. When the next dose is close, skip the forgot to take my dose and follow the standard dosing pattern. Never take a double dose to make up for a dose you missed.

Medicines, supplements and foods that can interact with isotretinoin

Keep from combining.

Use with caution. and discuss with your clinician

This enumeration is incomplete. Provide a complete list of prescription and non-prescription medicines, supplements and herbal products to your healthcare team. Also report alcohol use and smoking.

Network monitoring, risk mitigation measures and practical advice

For a list of serious adverse events see Off target effects.

Possible reactions to the medication

Seek immediate medical attention

Common but usually manageable

If minor effects persist or interfere with daily life, report them to your prescriber for advice on symptom relief or dose adjustment.

Encrypted efficient storage helps minimize clutter and maximize space.

Alternative drugs and similar pharmaceutical options

If isotretinoin is unsuitable, several other strategies may be considered depending on acne type and severity. Discuss options with your general practitioner or dermatologist.

For approximate cost differences see Competitive price comparisons in Australia.

AUD inflation-adjusted prices in Australia - rough guide

The following are indicative ranges. Actual cost varies with brand, dose, pharmacy, PBS status and your concession or safety net position.

Check with local pharmacies in conjunction with the PBS website for current subsidy and price list details.